NFE2L2 and cancer: It should also be taken into consideration that while Nrf2 plays a crucial role in maintaining cellular homeostasis under stress and inflammatory conditions, several studies have discussed a detrimental aspect of Nrf2 defined as the “dark side of Nrf2” in the cancer biology as enhanced Nrf2 activity is involved in a pro-carcinogenic effect and therapeutic resistance of cancer cells (Sporn and Liby, 2012).