Liu et al. (2020) used GeneCards and OMIM databases for the enrichment analysis and found that CA is closely related to the AKT/PI3K signaling pathway in breast cancer. Liu and Huang confirmed that CA regulated colorectal cancer and osteosarcoma progressing via the AKT/PI3K signaling pathway (Li et al., 2016; Huang et al., 2020). This evidence concerns the gene AKT1 and breast cancer.