AKT1 and rheumatoid arthritis: Therefore, we speculate that RA has a similar function in activating the PI3K/Akt signaling pathway, which is regarded as a critical event for survival and proliferation in various IR models (Dhanasekaran et al., 2008; Liu et al., 2020), while these effects could be abolished by coadministration with the PI3K specific inhibitor wortmannin, which binds to the p110 catalytic subunit of PI3K and irreversibly inhibits the enzyme (Ui et al., 1995; Ihara et al., 2020).