Aberrant mGlu5 signaling in AD mice has been observed to inhibit autophagy, the process by which cellular organelles and protein aggregates are cleared (Nixon, 2013), via ubiquitination and proteasomal degradation of the autophagy related 14 (ATG14) protein (Zhang et al., 2015; Abd-Elrahman et al., 2017). The gene discussed is GRM5; the disease is Alzheimer disease.