COMT and major depressive disorder: Furthermore, overrepresentation of Lactobacillus and Lactobacillaceae have often been seen as indicators of increased PD severity and duration, associating with PD duration, UPDRS-III total score, Hoehn and Yahr score, daily LED, adjuvant therapies for advanced disease (like COMT inhibitors and apomorphine), as well as decreased QoL, physical activity and increased depression severity (Lubomski et al., 2020b; Nishiwaki et al., 2020; Romano et al., 2021).