Separate and distinct correlative associations were identified for PD patients receiving standard therapies (Levodopa n = 92, Anticholinergics n = 13, COMT inhibitors n = 24, Amantadine n = 13, Dopamine agonists n = 36, MAO-B inhibitors n = 19) (Supplementary Table 1), with borderline moderate correlations between ASV_166/Bifidobacterium spp. The gene discussed is COMT; the disease is Parkinson disease.