In contrast, in mild AD patients, the brain regional function connection was increased between DLPFC.R and Broca's L. In addition, the activation of channel 36, which was located in the left primary somatosensory cortex, was significantly increased after 12-week of sport stacking, and this increased activation was correlated with the improved cognitive function (AVLT) as well as the increased level of BDNF. The gene discussed is BDNF; the disease is Alzheimer disease.