As is presented in Figures 3A,B,D, compared to MCI patients, significant lower Oxy-Hb concentrations during the task were exhibited in mild AD patients in channel 2, 4, 8, and 43 [mean with 95% CI, mAD vs. MCI, CH2: −0.0058 (−0.0205, 0.0088) vs. 0.0348 (0.0122, 0.0573), p = 0.006; CH4: −0.0054 (−0.0229, 0.01200) vs. 0.0329 (0.0137, 0.0521), p = 0.019; CH8: −0.0006 (−0.0142, 0.0129) vs. 0.0408 (0.0235, 0.0581), p = 0.008; CH43: −0.0053 (−0.0137, 0.0032) vs. 0.0354 (0.0178, 0.0530), p = 0.0004; all after FDR corrected]. Here, GSTM1 is linked to Alzheimer disease.