There were 22 patients that had non-pathogenic variants, including four variants of AD genes (Supplementary Table 2) that were classified as uncertain significance according to the ACMG recommendations (the population frequency and pathogenicity prediction of these four variants see in Supplementary Table 3), and 19 single heterozygous variants of AR genes (one patient carried two simple heterozygous variants; see details in Supplementary Table 4). Here, AR is linked to Alzheimer disease.