Of particular interest is mutations in PLA2G6 have been linked to several neurological diseases including infantile neuroaxonal dystrophy (INAD) (Khateeb et al., 2006), neurodegeneration with brain iron accumulation (NBIA) (Morgan et al., 2006), hereditary spastic paraplegia (HSP) (Koh et al., 2019a) and PD, but the underlying mechanism is still unknown. This evidence concerns the gene PLA2G6 and hereditary spastic paraplegia.