PLA2G6 and neurodegeneration with brain iron accumulation 2A: Of particular interest is mutations in PLA2G6 have been linked to several neurological diseases including infantile neuroaxonal dystrophy (INAD) (Khateeb et al., 2006), neurodegeneration with brain iron accumulation (NBIA) (Morgan et al., 2006), hereditary spastic paraplegia (HSP) (Koh et al., 2019a) and PD, but the underlying mechanism is still unknown.