Other drugs that could improve depression behaviors in 6-OHDA-induced PD models included Agametine (Souza et al., 2018), progesterone (Casas et al., 2011), granulocyte colony stimulating factor (G-CSF; Prakash et al., 2013), β3-adrenergic receptor agonist (Sampaio et al., 2019), Pioglitazone (Bonato et al., 2018), guanosine (Marques et al., 2019), Ketamine (Vecchia et al., 2018), imipramine (Vecchia et al., 2018), neuropeptide-S (Szot et al., 2016), Rapamycin (Masini et al., 2018) and Apamin (a selective blocker of small conductance calcium-activated potassium channels; Chen et al., 2014). Here, CSF3 is linked to major depressive disorder.