MAPT and Alzheimer disease: The United States National Institute on Aging – Alzheimer’s Association (NIA-AA) proposed a biological definition of AD, allowing for the diagnosis of AD in the presence of β-amyloid and neurofibrillary tau in cognitively healthy elders (Jack et al., 2010, 2018; Albert et al., 2011; McKhann et al., 2011; Sperling et al., 2011).