The logistic regression of the above results revealed nine key DE-ATGs: ATG16L2, BAK1, CAPN10, CASP1, RAB24, RGS19, RPS6KB1, ULK2, and WDFY3. Combined with age and sex, the diagnostic model of AD was established and presented as a nomogram. This evidence concerns the gene ATG16L2 and Alzheimer disease.