RSG19 is one of the G protein signaling-regulated genes, and the upregulated G protein could negatively regulate G protein-induced signaling transduction by inhibiting the activity of GNAI1, thus resulting in the dysfunction of cholinergic synapses in the nervous system (Xie et al., 2005) and the participation in the development of AD (Silver et al., 2012; Lee et al., 2016). The gene discussed is GNAI1; the disease is Alzheimer disease.