NR3C1 and alcohol dependence: On the other hand, GR in mPFC has been shown to be affected in a rat model of alcohol dependence (Somkuwar et al., 2017), and a GR antagonist has been demonstrated to decrease alcohol seeking in alcohol-dependent rats and humans (Vendruscolo et al., 2015) and to decrease binge drinking in male and female mice (Savarese et al., 2020).