MAPT and Alzheimer disease: Male and female 3xTg-AD mice (APPSwe, tauP301, Psen1tm1Mpm) which feature progressive amyloid (Aβ) and tau pathology, received chronic binge ethanol (5g/kg/day, 5-days-on/2-days-off, i.g.)or water during adulthood (from 5.5 to 9 months of age), followed by abstinence and assessment at 14 months of age.