Though originally identified in microglia in a model of cerebral amyloid angiopathy (5XFAD), dysfunction of key genes we found reduced by ethanol (e.g. APOE and TREM2) are well known risk factors for AD in general, and are involved in lipid metabolism, phagocytosis, and are known to influence tau pathology (Guerreiro et al., 2013; Jiang et al., 2014; Carmona et al., 2018; Yamazaki et al., 2019; Lee et al., 2021). Here, TREM2 is linked to Alzheimer disease.