Another study by Hoffman et al. (2019) using voluntary drinking (moderate exposure) in 10-week-old adult 3xTg-AD mice for 4 months showed increased levels of p-tau-199/202 in hippocampus and increased Aβ42/40 ratios in cortex that persisted one month into ethanol abstinence (7 months of age at assessment) with reduced memory retention in the probe trial of the Morris water maze. This evidence concerns the gene MAPT and Alzheimer disease.