Future studies in mice with acute, intermediate, and chronic CYP-induced cystitis that evaluate bladder function effects when imatinib is combined with other treatments (e.g., neuropeptide, cytokine, and chemokine receptor antagonists) should be considered (Arms et al., 2010, 2013; Gonzalez et al., 2013, 2014, 2016; Merrill and Vizzard, 2014; Girard et al., 2016, 2019, 2021; Guo et al., 2018; Tooke et al., 2019). The gene discussed is PPIG; the disease is chronic cystitis.