Although various in vivo and ex vivo approaches have been used to determine effects of imatinib on rat and guinea pig bladder function (Kubota et al., 2004, 2006; Biers et al., 2006; Kim et al., 2011; Abrams et al., 2012; Deng et al., 2013; Gevaert et al., 2014a; Kjell et al., 2015; Sancho et al., 2017; Giglio et al., 2018; Liu et al., 2018), we believe these studies are the first to use conscious, unrestrained cystometry to assess the effects of imatinib mesylate on urinary bladder function in mice with CYP-induced cystitis. Here, PPIG is linked to chronic cystitis.