We additionally assessed the effectiveness of imatinib at an intermediate CYP-induced cystitis time point (200 mg/kg, i.p., 48 h) with imatinib pre-treatment (gavage, 250 mg/kg, 7 total days) and found no significant differences in IMI or IV compared to vehicle treated groups or controls (Supplementary Figure 3). Here, PPIG is linked to cystitis.