Imatinib was effective at improving bladder function in mice with acute (4 h) CYP-induced cystitis for both the prevention (systemic gavage) and treatment (intravesical) designs, yet imatinib did not affect bladder function in mice with intermediate (48 h; gavage) or chronic (8 day; gavage and intravesical) CYP-induced cystitis. Here, PPIG is linked to chronic cystitis.