In mice with acute CYP-induced cystitis, imatinib treatment (transurethral intrabladder infusion, 50 μM, 0.5 mL, 30 min) or prevention (oral gavage, 250 mg/kg, 5 days) did not affect pelvic somatic sensitivity (Supplementary Figures 1, 2). This evidence concerns the gene PPIG and cystitis.