The second dose of imatinib, 24 h after CYP treatment significantly (p ≤ 0.05) increased IMI and IV compared to acute (4 h) CYP-induced cystitis before (p ≤ 0.001) and after the effects of a single dose of imatinib (p ≤ 0.01; Figures 7B,C). The gene discussed is PPIG; the disease is chronic cystitis.