We investigated the effects of PDGFRα blockade with imatinib in mice with intermediate (48 h) and chronic (8 day) CYP-induced cystitis using prevention (i.e., imatinib via oral gavage before CYP treatment) and treatment (i.e., CYP treatment followed by intrabladder infusion of imatinib) methods (Figures 5A, 6A and Supplementary Figure 3). This evidence concerns the gene PPIG and chronic cystitis.