In clinics, refractory severe migraines are effectively treated with prochlorperazine (i.v) (Friedman et al., 2017; Cook and Newberry, 2018), a seasoned phenothiazine drug which was identified in a repurposing screen to enhance KCC2 chloride extrusion function (Liabeuf et al., 2017). Here, SLC12A5 is linked to migraine disorder.