SLC12A5 and cancer: We were particularly interested in interrogating cancer drugs because a sizeable number of them impact epigenetic regulation of genes to inhibit cell growth, thus increasing our chances of finding gene-expression enhancers for Kcc2. This rationale is based on previous observations that the Kcc2 gene is critically regulated by epigenetic mechanisms (Yeo et al., 2013b; Yeo and Liedtke, 2020).