ADK and epilepsy: The current focus of gene therapy strategies for epilepsy is primarily aimed at reducing neuronal excitability by overexpressing neuro-modulatory peptides such as neuropeptide Y (Dong et al., 2013; Zhang et al., 2013), galanin etc. (McCown, 2006) or by the genetic modification of astrocytes, for example, to suppress adenosine kinase (ADK) expression (Young et al., 2014).