Supporting a crucial role for mTOR signaling in brain development, mutations in this pathway frequently lead to complex monogenic neurodevelopmental disorders (also known as mTORopathies), characterized by heterogeneous neuropsychiatric phenotypes that include megalencephaly, epilepsy, intellectual disability and autism spectrum disorder (ASD) (Moloney et al., 2021; Nguyen and Bordey, 2021). This evidence concerns the gene MTOR and epilepsy.