We established circRNA–miRNA–mRNA regulatory networks and identified 10 hub genes (ESR1, PTEN, SHC1, IGF1R, SMAD2, KRAS, MDM2, HIF1A, BMP4, and ACVR2B) that were closely related to PD by using PPI network analysis. This evidence concerns the gene ACVR2B and Parkinson disease.