PLAT and hematoma: More recent studies focused on minimally invasive surgery plus infusion of recombinant tissue plasminogen activator (rtPA) approaches show promise in early-stage clinical trials; however, the Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation III (MISTIE-III) trial observed a reduction in hematoma volume without significant functional improvement (Hanley et al., 2019).