In addition, we propose that FIN, triggered by HIV-1 infection and long-term cART use, may be counteracted by an epigenetic system comprised of bromodomain protein 4 (BRD4) and microRNA-29 (miR 29) that inhibits ferritinophagy by several mechanisms, including direct antiviral action, lysosomal suppression, SLC7A11 activation, and iron regulatory protein-2 (IRP-2) inhibition. Here, IREB2 is linked to HIV-1 infection.