This finding might seem counterintuitive given the preclinical and clinical evidence of reduced inhibition in TSC (White et al., 2001; Wang et al., 2007; Taki et al., 2009; Fu et al., 2012; Mori et al., 2012; Talos et al., 2012; Bateup et al., 2013; Aronica and Crino, 2014; Ruffolo et al., 2016; Nadadhur et al., 2019; Afshar Saber and Sahin, 2020; Haji et al., 2020) and the high epilepsy comorbidity in this group. This evidence concerns the gene TSC1 and epilepsy.