The pathway enrichment analysis for the genes in the 11 modules showed that genes in MCODE 2 (DES, MYH6, MYL2, MYL3, TPM1, TPM3, TPM4, and TTN) were significantly involved in dilated cardiomyopathy and hypertrophic cardiomyopathy (HCM), and genes in MCODE 4 (COL4A1, COL4A2, COL4A3, COL4A4, COL6A1, COL6A2, CTNNB1, and PDGFB) were mainly involved in focal adhesion, ECM-receptor interaction, and PI3K-Akt signaling pathway (Figure 4(c), Appendix Table 3). The gene discussed is COL4A1; the disease is dilated cardiomyopathy.