KRAS and carcinoma: In the present study, we identified that EMT displayed strong positive correlations with angiogenesis, hypoxia, coagulation, KRAS and TGFβ signaling pathways in the patients with early-stage LUAD, which correspond to other publications on the role of EMT in several types of carcinomas such as breast cancer, gastric cancer, lung cancer.10,35, , , -39 Besides EMT, apoptosis is another fundamental event that is tightly linked to the physiological and disease-related cellular processes.