NT5C and colorectal carcinoma: 2019). CDN inhibits tumorigenesis in CRC through regulation of microRNAs (miRNAs) expression (James et al. 2017, 2021). Increasing evidence has indicated that miRNAs play important roles in the development and treatment of CRC (Chen et al. 2019; Gmerek et al. 2019; Massaro et al. 2020; Wang H 2020). Other reports have also demonstrated the importance of STAT signal in regulation of CRC development (Jiang et al. 2019; Fang et al. 2020; Dariya et al. 2021).