PLG and COVID-19: Although the presence of D-dimer suggests fibrinolytic pathways are intact and actively dissolving (lysing) fibrin, the discovery of fibrin deposits in lungs and other organs suggests dysregulation of the balance in fibrin forming (i.e., thrombin generation) and fibrin-dissolving (i.e., plasmin generation) pathways is a major aspect of COVID-19 pathogenesis [51].