Jiang et al. examined serum samples from 30 IC/BPS patients and 26 controls and found significantly higher levels of C-reactive protein (CRP), interleukin (IL)-1B, IL-6, IL-8, and tumor necrosis factor-alpha (TNF-a) among those with IC/BPS [10]. This evidence concerns the gene IL1B and Bartsocas-Papas syndrome 1.