To the best of our knowledge, no effect of Probenecid has been evaluated on colorectal tumor; on the contrary, Quercetin anticancer properties have been investigated in a number of in vivo and in vitro studies that have proposed the involvement of different signaling pathways such as PI3K, MAPK and toll-like receptor 4/NF-κB [47]. Here, TLR4 is linked to colorectal neoplasm.