Interestingly, abnormalities in membranous bones observed in Tbx1-null mice are similar to those of cleidocranial dysplasia (OMIM #119600 and #216330) in humans, exhibiting hypoplastic membranous bones, including abnormal neurocranial morphology, a short clavicle, a hypoplastic zygomatic arch, and hyoid bone [73,74,75]. Here, TBX1 is linked to cleidocranial dysplasia 1.