IL-6 significantly contributes to immune dysregulation in COVID-19 by acting in two main pathways: on the one hand, this cytokine may lead to a dysfunction of natural killers (NK) cells and cytotoxic CD8+ T-cells, suppressing antiviral defenses [45]; on the other hand, it may stop the differentiation of T reg cells, raising Th 17 polarization of CD4+ T-cells, thus leading to unrestrained hyperinflammation [46]. This evidence concerns the gene IL6 and COVID-19.