Indeed, with upregulation of Hsps (Hsp40 and Hsp70) in HD models, there is evidence for differential effects: many show a decline in aggregation (Jana, 2000; Zhou et al., 2001; Hay, 2004; Guzhova et al., 2011; Labbadia et al., 2012; Maheshwari et al., 2014; Scior et al., 2018), some show no effect (Wyttenbach et al., 2000; Karpuj et al., 2002; McLear et al., 2008), and one study shows an increase in aggregation (Wyttenbach et al., 2000). The gene discussed is DNAJB1; the disease is Huntington disease.