Improving clock function and sleep in HD mice have been neuroprotective (Pallier et al., 2007; Maywood et al., 2010; Ouk et al., 2017; Wang et al., 2017; Whittaker et al., 2018), whereas clock disruptions worsen ND (Krishnan et al., 2012; Lauretti et al., 2017; Kim et al., 2018; Sharma and Goyal, 2020). The gene discussed is CLOCK; the disease is Huntington disease.