As shown in Fig. 5A, the levels of serum KIM-1 were elevated at 1 week (1189.3±111.5 pg/ml) after administration of adenine and potassium oxonate and further increased at 4 weeks (2500.1±222.8 pg/ml), suggesting that renal dysfunction was aggravated during disease progression. This evidence concerns the gene HAVCR1 and Abnormal renal physiology.