Da et al. proposed that CASK may be a tumor suppressor and an independent prognostic marker for CCA using bioinformatics combined with quantitative proteomics,16 while Zhang et al. identified 191 novel methylation‐regulated DEGs for CCA that were enriched in the cell cycle, nuclear division, xenobiotic metabolism, drug catabolism, and negative regulation of proteolysis based on the results of an integrated bioinformatics analysis.17 The gene discussed is CASK; the disease is cholangiocarcinoma.