The ameliorating effects of a combination of THC and CBD on a murine model of experimental autoimmune encephalomyelitis (EAE) were linked to changes in the microbiome, specifically reduction in mucin degrading species such as Akkermansia muciniphila which were increased in the gut of EAE mice (Al-Ghezi et al. 2019). The gene discussed is MUC5AC; the disease is experimental autoimmune encephalomyelitis.