The analysis of the effects of sustained SIAP2 consumption on CMD risk factors, which could be partially due to changes in the gut microbiota composition, in subjects with abdominal obesity revealed a significant decrease in the PP in women in the SIAP2 group and significant decreases in insulin and HOMA-IR in the SIAP2 group, particularly in men, compared with the placebo group, at 12 weeks. This evidence concerns the gene INS and Abdominal obesity.