For proving the effect of Mφ-Exo-circBTG2 on the modulation of glioma growth in vivo, U87 MG cells undergoing transfection with sh-circRNA or sh-NC or coculture with WT Mφ-Exos, RBP-J OE Mφ-Exos or (RBP-J OE + sh-circRNA) Mφ-Exo were subcutaneously injected into nude mice. The gene discussed is RBPJ; the disease is glioma.