On the other hand, both LC3B-II/I ratio (sham vs. AS: 0.36 ± 0.29 vs. 1.39 ± 0.57 a.u.; P < 0.01) and OPA1 (sham vs. AS: 1.04 ± 0.49 vs. 1.52 ± 0.13 a.u.; P < 0.05) were significantly increased in AS. The gene discussed is OPA1; the disease is aortic valve stenosis.