CD8A and vitiligo: IFNγ, and the genes it induces, encode the CXCR3 chemokine receptor and its ligands CXCL9 and CXCL10, which are critical for the activation of CD8+ T cells, and are found to be increased in the skin and blood of patients with vitiligo.83, 84 CXCL9 promotes the global recruitment of autoreactive T-cells but with no effector action, whereas CXCL10 is required for disease progression and maintenance.85