KV7.2 and KV7.3 are broadly expressed in neurons, where they form heterotetrameric KV7.2/7.3 channels, and mutations to these channels may give rise to epilepsy or chronic pain (Biervert et al., 1998; Nappi et al., 2020; Wang et al., 1998). Here, KCNQ2 is linked to epilepsy.