Recent findings have shown that local infusion of ketamine activated cortical neurons and alleviated anxiety‐related behaviors.[49] Given that both ketamine[50, 51] and exercise[17] can activate the mechanistic target of rapamycin (mTOR)‐directed spinogenesis and neural activities, physical exercise may have anxiolytic and antidepressant actions with long‐lasting effects. The gene discussed is MTOR; the disease is Anxiety.