Brain RNA m6A homeostasis is well orchestrated by various factors, of which Mettl3 and Mettl14 have been established to play roles in cognitive and mental functions.[11, 25, 26] Regarding RNA demethylase, Fto mediates methylation status in psychiatric diseases[40] or neurodegenerative disorders.[41] Upon acute stress, Fto was slightly upregulated in the PFC,[11] whereas we found no significant changes under CRS. Here, METTL3 is linked to psychiatric disorder.