More importantly, our results support clinical observations showing the effectiveness of neural stimulation of the PFC in alleviating anxiety‐related behaviors.[52] To provide the molecular substrate, we found that RNA demethylation of this PrL‐BLA circuit is sufficient to reverse exercise‐mediated effects, providing the first piece of evidence for the role of m6A within a specific neural circuit for mediating behavioral phenotypes. Here, PRL is linked to Anxiety.