ALKBH5 and major depressive disorder: [44] Another demethylase, Alkbh5, presented potentiated expression in the CRS group, in agreement with previous findings in acute stress.[11] In mouse depression models, ALKBH5 displayed nuclear redistribution to direct methylation of the fatty acid amide hydrolase (FAAH) gene.[45] It is worth noting that a gene polymorphism of Alkbh5 was previously found to be related to MDD risk in the Chinese Han population.[46] These data support the role of RNA demethylases in mental functions.