There is evidence that this leads to changed alternative splicing patterns in DM1, with MBNL1 and CUGBP1 acting antagonistically as splicing regulators (de Haro et al., 2006; Konieczny et al., 2014; Pettersson et al., 2015; Wang et al., 2015). This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.