Lens cataract is the most prevalent symptom in DM1 (Romeo, 2012; Smith and Gutmann, 2016), and we have previously determined that the CUGexp foci in HLECs derived from DM1 patients contain only 0.2-0.5% of cellular MBNL1 (Coleman et al., 2014), making sequestration of MBNL1 within the foci an unlikely explanation for DM1-associated cataract. This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.