We found that the absence of FMOD neither affected GSC growth and differentiation to DGC (Figure 2—figure supplement 1, Figure 2—figure supplement 2, Figure 2—figure supplement 3) nor DGC growth and reprogramming to form GSCs (Figure 2—figure supplement 4, Figure 2—figure supplement 5, Figure 2—figure supplement 6; more details in Appendix 1), consistent with our previous findings showing that FMOD does not affect glioma cell proliferation in vitro (Mondal et al., 2017). This evidence concerns the gene FMOD and central nervous system cancer.