FMOD and central nervous system cancer: DBT-Luc GSC/miRFMOD, another murine glioma GSC cell line, produced similar results: FMOD silencing after doxycycline administration resulted in reduced tumor growth (Figure 5—figure supplement 1A B), increased mice survival (Figure 5—figure supplement 1C), and decreased FMOD expression (Figure 5—figure supplement 1D).