In addition, the DGCs used in this study that express a high level of FMOD showed enrichment in mesenchymal signature compared to GSCs (Figure 1—source data 10), consistent with the elevated TGF TGF-β signaling and FMOD levels we observed in the mesenchymal GBM subtype (Figure 1—figure supplement 3A B). This evidence concerns the gene TGFB1 and glioblastoma.