Toward exploring the possible role of DGC-secreted FMOD in glioma tumor growth, we first investigated the role of FMOD in GSC and DGC growth and interconversion between both cell populations in vitro using two human (MGG8 and U251) and two murine (AGR53 and DBT-Luc) glioma cell lines. Here, FMOD is linked to central nervous system cancer.