In addition, HSPA6 has been confirmed to enhance the effect of garlic extract‐induced signaling cascade of ATM‐CHK2‐CDC25C‐p21WAF1‐CDC2 and phosphorylation of MAPK and AKT signaling to arrest bladder cancer EJ cell to G2/M phase,52 implying the closely correlation between HSPA6 and cell cycle progression. The gene discussed is CHEK2; the disease is urinary bladder carcinoma.