Hypoxia-induced expression of PDL1 (encoded by the CD274 gene) and production of adenosine by cancer cells through the activity of CD73 (encoded by the NT5E gene) lead to immunosuppression (Supplemental Table 3) via binding to cognate receptors (PD-1 and adenosine receptor 2A, respectively) on NK and CD8+ T cells that results in exhaustion or apoptosis. The gene discussed is CD8A; the disease is cancer.