Importantly, comparing 4 BRCA1 mutated (HCC1739, MDA-MB-436, Sum1315MO2, and Sum149PT) and 4 BRCA1 wild-type (BT549, MDA-MB-231, MDA-MB-436, and CAL15) TNBC cell lines, ARN3261 significantly inhibited tumor cell growth in all 8 cell lines tested regardless of BRCA1 mutation status (Figure 1A and Supplemental Figure 1A). The gene discussed is BRCA1; the disease is neoplasm.