CD8A and HIV infectious disease: In this issue of the JCI, Perdomo-Celis et al. used a pan–glycogen synthase kinase 3 (GSK-3) inhibitor, targeting the TCF-1/Wnt/β-catenin pathway to induce TCF-1 and its transcriptional activity, which reprogrammed dysfunctional CD8+ T cells in HIV infection (15).