Remarkably, however, all stimuli (amino acids, low glucose, high glucose, and 3-isobutyl-1-methylxanthine [IBMX]) enhanced insulin secretion by T1D islets in a pattern similar to that seen in normal islets (Figure 2A; shown as a percentage of content in Supplemental Figure 1C). The gene discussed is INS; the disease is type 1 diabetes mellitus.