This was consistent with our findings that high-expressed FOXD2-AS1 could predict a poor survival and that tumor related pathways such as P53 signaling pathway and cell cycle were mainly the KEGG enrichment pathways of target genes regulated by FOXD2-AS1, indicating that the analysis of whole genome lncRNA CNV to identify prognosis of thyroid cancer was an effective and reliable approach. This evidence concerns the gene TP53 and thyroid gland carcinoma.