This was consistent with our findings that high-expressed FOXD2-AS1 could predict a poor survival and that tumor related pathways such as P53 signaling pathway and cell cycle were mainly the KEGG enrichment pathways of target genes regulated by FOXD2-AS1, indicating that the analysis of whole genome lncRNA CNV to identify prognosis of thyroid cancer was an effective and reliable approach. This evidence concerns the gene TP53 and thyroid cancer.