For example, BMPR2, BRD7, PRKAG2, PRKAR1A and PPP2R2A (PP2A Bα subunit B55α), which are differentially expressed between group V (H+V−S+[M/T]) and groups II/IV (H+V+S−/H+V−S+[M]), play roles in tobacco-mediated lung diseases and lung cancers [69–76]. The gene discussed is BMPR2; the disease is lung carcinoma.