HSPA5 and ovarian carcinoma: OTUD1 is negatively regulated by miR-4429 in ovarian cancer, and the expression of YOD1 increases when miR-4429 is reduced, promoting the growth and metastasis of ovarian cancer. OTUD3 can promote the occurrence of lung cancer by stabilizing GRP78 (The glucose-regulated protein 78 kDa, Bip) [8], OTUD4 [9], OTUD5 [10], and OTUD6B [11] also play important roles in the pathogenesis of different tumors.