As shown in Additional file 1: Fig. S3, the high expression of YOD1 in PAAD is highly correlated with adhesion, metastasis, invasion, Gefitinib chemotherapy resistance, DNA repair, tumor hypoxic microenvironment and p53, Notch, NRG1, MYC, EGFR, Hippo signaling pathway. The gene discussed is EGFR; the disease is pancreatic adenocarcinoma.