TP53 and neoplasm: Next, we investigated the potential signaling pathway of YOD1 in PAAD by GSEA and Linkedomic functional enrichment analysis. Analysis suggested that YOD1 was related to intercellular adhesion, p53, Hippo pathway, metastasis, drug resistance, etc. Imbalanced intercellular adhesion is characteristic of many pathological conditions that can lead to increased tumor invasion and metastasis. The enrichment of YOD1 co-expressed genes also enriches the Hippo pathway.