YOD1 and familial pancreatic carcinoma: It was found that the expression of YOD1 in 6 PAAD cells was higher than normal pancreatic cells HPDE6-C7 (Fig. 8A). Further, we compared the expression of YOD1 protein in the cancerous tissues with the adjacent tissues more than 5 cm away from the cancerous tissues of the six pancreatic cancer patients by Western blot and IHC experiments, and we found that the expression of YOD1 in the cancerous tissues was higher than that in the adjacent tissues (Fig. 8B, Additional file 1: Fig. S6A).