We selected MIA-PaCa-2, a pancreatic cancer cell with low YOD1 expression, and AsPC-1, a metastatic pancreatic cell with a high degree of malignancy. YOD1 was highly expressed in MIA-PaCa-2 cells, and YOD1 was knocked down in AsPC-1 cells. Here, YOD1 is linked to familial pancreatic carcinoma.