BRAF and colorectal carcinoma: Liver resection is the preferred treatment for CRLM with a 5-year survival rate of 20–50%, which is location-dependent (liver metastasis on the right side of primary CRC has a worse prognosis than that on the left side), and it is consistent with the invasiveness and poor prognosis mediated by mutation of some genes (for example, BRAF-V600E mutant CRLM with aggressive biological behavior is more likely to occur on the right side of primary CRC) [2].