This recent study showed that this mutation leads to a non-canonic activation of SGK1 (serum/glucocorticoid-regulated kinase 1) which is implicated in various neoplasms (as breast cancer, hepatocellular carcinoma, glioblastoma, colorectal cancer and non-small cell lung cancer) [75–79]. This evidence concerns the gene SGK1 and hepatocellular carcinoma.